ACTA1 and Hepatic fibrosis: As a pathological process, hepatic fibrosis initiates the disruption of normal live architecture by enhancing the deposition of extracellular matrix (ECM) as part of the healing process initiated in response to continuous injury to the liver tissue Hepatic fibrosis is characterized by the trans-differentiation of hepatic satellite cells (HSCs) to α-smooth muscle actin (α-SMA)-positive myofibroblast cells with enhanced synthesis of ECM components 2.