Numerous studies have demonstrated the impact of life behaviours or motivations on cigarette consumption and nicotine dependence 8, 9, such as working time10, socioeconomic pressure11, caffein exposure12, alcohol7, sleeping time13, 14, CYP2A6 gene type15, etc. Nowadays, there are many treatment options and methods for nicotine addiction16. This evidence concerns the gene CYP2A6 and nicotine dependence.