Garlic and its derivatives can mitigate the hepatic steatosis by down-regulating the expression of sterol regulatory element-binding protein-1c (SREBP1c) and up-regulating the expression of peroxisome proliferator-activated receptor α (PPAR α ) and carnitine palmitoyltransferase-1 (CPT-1) 32. This evidence concerns the gene SREBF1 and fatty liver disease.