Type 2 diabetes is a common observation in BBS patients.42, 43 Using BBS mice, we demonstrated that this phenotype is due to mis-trafficking of the insulin receptor.28 Our current investigation revealed the importance of Bbs1 gene in POMC neurons for the regulation of glucose metabolism and insulin sensitivity as indicated by the glucose intolerance and insulin resistance observed in POMCCreERT2/Bbs1fl/fl mice. Here, INSR is linked to type 2 diabetes mellitus.