However, they are of non-human origin, and they do not recapitulate the composition of the tumour ECM in patients (i.e. collagen does not recapitulate the molecular complexity of the tumour ECM and Matrigel primarily consists of basement membrane proteins, such as laminin 111 and collagen IV, entactin and heparan sulfate proteoglycan [14]). Here, CD44 is linked to neoplasm.