TNF and Mental deterioration: A complex crosstalk between infiltrating macrophages and brain-resident cells leads to the release of cytokines, including interleukin (IL) 1β, IL-6, IL-8, tumor necrosis factor (TNF) α, monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein (MIP)-1α, reactive oxygen species, and proteolytic enzymes, all of which contribute to neuroinflammation, and ultimately, neurodegeneration and cognitive decline [5].