Some polyphenolic compounds(such as chlorogenic acid and wogonoside) have been shown to inhibitthe NLRP3 inflammasome, thus preventing colitis.38,44 In our previous study,23 SA could inhibitthe NLRP3 cascade reaction and inflammation in DSS-fed mice with colitis.This study further validated the results, demonstrating the importanceof preventing the activation of NLRP3 in inhibiting inflammation. The gene discussed is NLRP3; the disease is colitis.