Beclin1is a key participant in autophagy and regulates the synthesis andmaturation of autophagosomes.16 In theTNBS mouse model of chronic colitis, the autophagy indicator LC3-BII/Iratio was reduced, and inflammatory and fibrogenic factors were increased,58 promoting intestinal fibrosis.61 The present study also found that the expression of Beclin1and LC3 was increased, and that of p62 was decreased by SA intervention,demonstrating that SA can inhibit the occurrence of chronic colitisand colonic fibrosis by regulating autophagy. Here, MAP1LC3A is linked to Chronic colitis.