Previous investigation elucidated that silibinin induced autophagy via enhancing AMP/ATP ratio, which transduced inhibitory signals to phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha‐protein kinase B–mammalian target of Rapamycin (mTOR) pathway in colorectal cancer cells.89 The gene discussed is MTOR; the disease is colorectal cancer.