CR2 and nonpapillary renal cell carcinoma: To define the maturation of TLS in ccRCC, we implemented an IHC assay to evaluate aggregates of lymphocytes that have histological features with analogous structures to lymphoid tissues with CD3+ T cells, CD20+ follicular B cells, CD21+ FDCs infiltration, and CD23+ GC cells in serial sections (Figures 1B–D).