PCOS participants showed significantly lower mean values of FSH, E2, and SHBG in comparison to the controls (5.22±1.67 mIU/mL vs. 6.13±1.23 mIU/mL, p<0.001; 45.63±18.64 pg/mL vs. 87.03±13.38 pg/mL, p<0.001, and 41.78±11.27 nmol/L vs. 64.51±19.46 nmol/L, p<0.001, respectively). Here, SHBG is linked to polycystic ovary syndrome.