PCOS: polycystic ovary syndrome; BMI: body mass index; WC: Waist circumference; WHR: Waist-to-hip ratio; mFG: modified Ferriman–Gallwey; HOMA-IR: Homeostatic Model Assessment–Insulin Resistance Index; LH: luteinizing hormone; FSH: follicle-stimulating hormone; E2: 17b-estradiol; TT: total testosterone; DHEAS: dehydroepiandrosterone sulfate; PRL: prolactin; SHBG: sex hormone-binding globulin; TSH: thyroid-stimulating hormone; Ca: calcium; P: phosphorous; ALP: alkaline phosphatase; PTH: parathyroid hormone; 25-OHD: 25-hydroxy vitamin D. The gene discussed is BRD2; the disease is Insulin resistance.