Mean HOMA-IR and insulin levels were significantly higher in PCOS women compared to controls (3.44±1 .93 vs. 1.58±1.25, p<0.001; 16.40±8.67 IU/mL vs. 8.09±5.23 IU/mL, p<0.001, respectively). This evidence concerns the gene INS and polycystic ovary syndrome.