INS and Insulin resistance: Changes in metabolic parameters such as fasting glucose (FG), fasting insulin (FI), homeostatic model assessment-insulin resistance (HOMA-IR), glycosylated hemoglobin (HbA1c), low-density lipoprotein (LDL), and triglycerides (TG) values before starting treatment and at the four and 16 weeks are summarized in Table 3.