Certain medications like chloroquine, hydroxychloroquine, and azithromycin can prolong the QT interval, posing risks for cardiac patients. When using antipsychotics for delirium, be cautious, especially in cardiac patients; consider alternatives like alpha-2 agonists or antiepileptics for high-risk cases. Melatonin helps with sleep-wake disturbances, while benzodiazepines should be a last resort for highly agitated patients. In anxious patients with respiratory distress, carefully weigh the use of low-dose benzodiazepines. This evidence concerns the gene PSMA2 and Respiratory distress.