ACE and Renal insufficiency: ACE inhibitors have the teratogenic effects of skull hyperplasia, anuria, hypotension, renal failure, lung hypoplasia, skeletal deformation, oligohydramnios, and death in the fetus. With the proper education on teratogenic agents and their effects, a mother can prevent her fetus from developing these severe developmental abnormalities if she avoids these agents, especially during the high susceptibility period.