RAG1 and Stroke: In the acute stage of stroke, using an anti-CD20 antibody Pharmacologic depletion of B cells, lack of circulating B cells in JHD−/− mice or reconstitution of Rag1−/− mice with B cells did not influence infarct volumes and functional outcome at day 1 and 3 after stroke (19), but cell adoptive transfer to mice reduced infarct volumes 3 and 7 d after transient middle cerebral artery occlusion.