The top five KEGG pathways for CXCR4 were allograft rejection, hematopoietic cell lineage, autoimmune thyroid disease, systemic lupus erythematosus, and type I diabetes mellitus; for NFE2L2 were drug metabolism-cytochrome P450, endocytosis, metabolism of xenobiotics by cytochrome P450, olfactory transduction, and spliceosome (Figure 6a). Here, NFE2L2 is linked to type 1 diabetes mellitus.