Considering the medical and epidemiological importance of HDV infection in WesternAmazon; the remarkable influences of SNPs rs8099917 (IFNL3) and rs1800795 (IL-6)against HBV and HCV infections and liver disease development [5]; lack of studies on their influence in HDV infection, thisstudy aims to evaluate possible influences of these SNPs on the development ofchronic liver disease (CLD) associated with Delta hepatitis in patients residing inlocations of Western Amazon. Here, IFNL3 is linked to congenital secretory chloride diarrhea 1.