The relationship between viral infections and host factors holds high hopesfor identifying the role of Interferon Lambda 3 (IFNL3) and Interleukin 6(IL-6) polymorphisms in the development of Chronic Liver Disease (CLD) inpatients infected with hepatitis Delta virus (HDV) in the Western BrazilianAmazon. This evidence concerns the gene IFNL3 and viral infectious disease.