DAT‐knockout (KO) mice recapitulate major human DTDS motor features, including progressive motor deficits, dyskinesia, tremors and metabolic profiles of high HVA and low DA; shortened lifespan with parkinsonism and reduced TH levels were also found in these mice.105, 106, 107. The gene discussed is SLC6A3; the disease is SLC6A3-related dopamine transporter deficiency syndrome.