Our recent study also found that obesity-induced palmitic acid elevation promotes inflammation and glucose metabolism disorders in mouse adipocytes through the GPRs (GPR40 and GPR120)/NF-κB/KLF7 signaling pathway, in which the active subunit p65 of NF-κB activates KLF7 expression by targeted transcription after nuclear entry [39]. This evidence concerns the gene FFAR4 and obesity due to melanocortin 4 receptor deficiency.