MiR-29a-3p, a member of the miR-29 family that significantly increases in OSCCs,56 exerts effects on M2 polarization through the suppressor of cytokine signaling 1 (SOCS1)/signal transduction and the transcriptional activator (STAT) pathway.57 The CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6)58 and heat shock protein-90 (HSP-90)59 are important proteinic influencers of M2 macrophage conversion, indicating novel crosstalk between cancer cells and immune-modulation. This evidence concerns the gene SOCS1 and cancer.