Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a tumor-suppressing factor, and its expression is downregulated in OSCCs.36 Exosomal miR-130b-3p derived from OSCCs cells and miR-23b-3p from salivary adenoid cystic carcinomas (SACCs) cells negatively regulate PTEN expression, promoting migration and angiogenesis in HUVECs.37,38 miR-221s and miR-210-3p also regulated HUVECs angiogenesis through the PI3K/AKT pathway.39,40 Besides cancer cells, the mesenchymal stem cells (MSCs) in oral carcinomas can secrete angiogenesis-stimulative exosomes. Here, PTEN is linked to lip and oral cavity carcinoma.