Consistently, Bim-/-lpr mice exhibited the most severe lupus syndrome, including splenomegaly (Supplementary Fig. 7a), the accumulation of autoantibodies (Supplementary Fig. 7b, c), renal destruction (Supplementary Fig. 7d–g) as well as increased inflammatory cytokine level (Supplementary Fig. 7 h). The gene discussed is BCL2L11; the disease is Splenomegaly.