Moreover, DN T cells produce significant amounts of IFN-γ and IL-17, which can promote the development of SLE.5–7 As a result, the homeostasis of DN T cells is critical for lupus pathogenesis.6,8–10 Thus, elucidation of the signaling events mediating the homeostasis of DN T cells could provide new potential therapeutic options for SLE. The gene discussed is IFNG; the disease is systemic lupus erythematosus.