To elucidate how ALKBH5 regulats GBM angiogenesis, we selected FGFR1, VAV2 and VEGFA as potential downstream angiogenesis regulator according to the bioinformatic results (Fig. 2A), and verified the expression levels of FGFR1, VAV2 and VEGFA in ALKBH5-knock-down U87 cells. This evidence concerns the gene VEGFA and glioblastoma.