In fact, humans with complete genetic deficiency of ANGPTL3 exhibit familial combined hypolipidemia (FHBL2) and associated reductions in very low-density lipoprotein (VLDL) cholesterol, LDL, and HDL (6, 7, 8, 9, 10). Here, ANGPTL3 is linked to familial hypobetalipoproteinemia 2.