In lip cancer and Squamous Cell Carcinoma the immunoexpression of CD3+ (p =  0.002, r = 0.474), CD8+ (p =  0.001, r = 0.521) and CD68+ (p =  0.030, r = 0.363) showed direct correlation between intra and peritumoral region (Table 4). The gene discussed is CD68; the disease is lip cancer.