Despite the limitations of our study, we were able to plainly evaluate the transposition of Aquitic Cheilitis to lip cancer and Squamous Cell Carcinoma, showing the interaction of cells in the tumor microenvironment and noting that macrophage is the first interacting cell that has the greatest ability to migrate into the tumor and interact with CD3, CD8, and CD20. The gene discussed is CD8A; the disease is lip cancer.