Biomarkers could also potentially suggest which therapies are most likely to be effective for a particular patient, facilitating personalized treatment.29 In this study, EGR1, EGR3, and CRY2 were selected based on their potential to mediate gene-environment effects on psychopathology and based on previously reported association with psychiatric disorders,5,11,12,24,28,30–33 including studies from our group.15,20. Here, CRY2 is linked to psychiatric disorder.