Our findings showing reduced EGR1 mRNA levels in the blood of SZ individuals compared to controls corroborate other studies.39,40 However, a study investigating transcriptional signatures in major psychiatry disorders reported EGR1 upregulation in fibroblasts and whole blood from SZ patients experiencing elevated psychotic states compared to controls and this altered EGR1 expression was not observed in MDD or BD.41 Although findings conflict, this evidence suggests involvement of the EGR1 gene in the pathophysiology of SZ. Here, EGR1 is linked to major depressive disorder.