By analyzing the expression of circulating Th17, Treg, Tfr, and Tfh cells, our study found that in the new-onset patients with RA, the ratio of Tfh/Tfr was aberrant, and Treg and c-Tfr cells were reduced and associated with the disease activity and the abnormal autoantibodies of RA negatively, but the expressions of Th17 and c-Tfh cells were not increased significantly. This evidence concerns the gene TFRC and rheumatoid arthritis.