METTL3 and acute respiratory distress syndrome: Interestingly, some studies have shown that neutrophil extracellular traps (NETs) induced ferroptosis in alveolar epithelial cells of cecal ligation and puncture (CLP)-mouse model by activating METTL3, while a few studies showed METTL3-mediated m6A modification alleviated ALI via inhibiting endothelial injury, indicating that m6A may exert different effects on ALI/ARDS owing to cell types and challenges [29–31].