The TAD structural changes involve the vascular endothelial growth factor gene VEGFA, which is a major tumor angiogenic gene that is over-expressed in leukemia (see reviews43,44 for more details), consistent with the fact that K562 cells are chronic myelogenous leukemia cells. Here, ENSG00000279284 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.