The annual main keywords evolution chart reveals (Fig. 5B) that the main keywords in 2022 was autophagy; 2021 included immunogenic cell death, tumor-associated macrophages, targeted delivery, natural killer cells, hypoxia, antitumor-activity, antibody and in 2020 included delivery, T cells, etc. The main keywords in 2019 included dendritic cells, drug delivery, regulatory T cells, etc. The earlier keywords included vaccine delivery, antigen cross-presentation, cd4(+) t-cells, etc. The gene discussed is CD4; the disease is neoplasm.