Most of the MRGs were not significantly different among other clinical factors, except SNCA (P < 0.05) and E2F1 (P < 0.05) in Grade (Supplementary Fig. S1B), CSNK2A2 (P = 0.02) in Age (Supplementary Fig. S1C), TIGAR (P < 0.05) and MTX1 (P < 0.05) in Macroscopic disease (Supplementary Fig. S1D). Here, TIGAR is linked to glycogen storage disease VI.