More importantly, FAM46C, SLC7A7, LY96, CFI, DDIT4L, CD14, C5AR1 and IGJ were the most significant crosstalk genes between periodontitis and MS, and CFI, DDIT4L, FAM46C can be used as potential biomarkers for the diagnosis of periodontitis and MS. The gene discussed is LY96; the disease is periodontitis.