The results of the multivariate regression analysis demonstrated that being male (OR = 2.702, 95% CI: 1.290–5.658, P < 0.01), having a DM history (OR = 2.329, 95% CI: 1.077–5.035, P < 0.05), being a current smoker (OR = 2.702, 95% CI: 1.204–6.066, P < 0.05), LPa (OR = 1.006, 95% CI: 1.000–1.012, P < 0.05), IL-6 (OR = 1.173, 95% CI: 1.082–1.271, P < 0.001) and ceramide (d18:1/16:0) (OR = 1.018, 95% CI: 1.008–1.028, P < 0.001) were all significant predictors of ACS. This evidence concerns the gene IL6 and diabetes mellitus.