Given the correlation between HMGB1 and the NLRP3 inflammasome, the aim of the current study was to investigate whether HMGB1-induced activation of the NLRP3 inflammasome contributes to generation of FS by evaluating the protein expression levels of HMGB1, NLRP3, caspase-1, IL-1β, IL-6, and TNF-α in the peripheral serum of FS patients. The gene discussed is CASP1; the disease is Feingold syndrome.