While downstream signals activated by LYVE1 as a hyaluronan receptor on LECs are not well characterized, LYVE1 is a homolog of CD44, which is also hyaluronan receptor known to activate lymphocytes, direct circulation of lymphocytes, and aid in tumorigenesis and lymph node metastasis in breast cancer [35–39]; thus, LYVE1 may serve a similar function as CD44 in LECs. The gene discussed is CD44; the disease is metastatic malignant neoplasm in the lymph nodes.