For example, bone marrow-derived macrophages (BMDMs) can express LYVE1, PROX1, and PDPN, and form lymphatic-like structures in vitro [47] and LYVE1 + PROX1 + PDPN + bone marrow derived cells undergo lymphatic vascular mimicry during neo-lymphangiogenesis in VEGFC-expressing pancreatic tumors in mice [47]. This evidence concerns the gene PROX1 and pancreatic neoplasm.