ABCC8 and epilepsy: Neuronal KATP channels, involved in nutrient and metabolic sensing, have been shown to play neuroprotective roles in ischaemia and protect against hypoxia- and drug-induced epilepsy, where channel activation reduces excitability.58-61 SUR1 is reportedly the predominant subunit in most neuronal populations,62,63 although SUR2 mRNA has been identified in multiple neurons in rodents, including hippocampal CA1 pyramidal and dentate gyrus granule cells, and dopaminergic excitatory neurons of the substantia nigra pars compacta.