A key role for SUR2-dependent KATP channels in the cerebral vasculature is also emerging, with smooth muscle or pericyte KATP activation associated with neurovascular coupling.66 Cerebrovascular abnormalities are also seen in Cantú syndrome, including white matter hyperintensities that potentially arise from abnormal cerebral blood flow. This evidence concerns the gene ABCC9 and hypertrichotic osteochondrodysplasia Cantu type.