VWF and cancer: As for the DNA methylation, the cancers and the corresponding genes with hypermethylation were as follows: BRCA: VWF and ITGB3; COAD: QKI, DUSP9, and CNKSR2; KIRC: CNKSR1; PRAD: VWF, LMNA, and ITGB3; UCEC: ITGB3 and APBBAIP (Figure 1E).