Specifically, the phosphorylation level at the T453 locus within the XRCC1 protein was significantly elevated in breast cancer, colon cancer, LUAD, UCEC, and pancreatic adenocarcinoma compared to normal tissues (all P < 0.05) (Figure 5B, 5D, 5E, 5G, 5H). The gene discussed is XRCC1; the disease is breast cancer.