In parallel, RAB9A has been shown to activate the AKT/mTOR signalling pathway involved in cancer progression, as well as to inhibit apoptosis and promote invasion and migration of hepatocellular carcinoma cells [40]; SGTB can be regulated by multiple miRNAs thereby deregulating a negative mechanism for cancer progression [41, 42]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.