Finally, feature genes that overlapped between these two algorithms were obtained: DDR2, EGFL6, LOXL1, FGF9, LAMA3, THBS1, NID1, NID2 and MMP14, which are localized on the basement membrane and may be involved in the development of rheumatoid arthritis (Figure 3D). This evidence concerns the gene NID1 and rheumatoid arthritis.