Finally, feature genes that overlapped between these two algorithms were obtained: DDR2, EGFL6, LOXL1, FGF9, LAMA3, THBS1, NID1, NID2 and MMP14, which are localized on the basement membrane and may be involved in the development of rheumatoid arthritis (Figure 3D). Here, DDR2 is linked to rheumatoid arthritis.