The identified membrane proteins serve as receptors (EPHB6, ACKR1, and EDNRB) or adhesion molecules (EPCAM) and may enhance antitumor immunity (TENM2 and CLEC‐10A); thus, they may contribute to enhanced mEHT‐induced cancer destruction through regulating the TME related immune response. The gene discussed is EDNRB; the disease is cancer.