In this study, we simulated the natural pathogenesis of human obesity and prepared obese and diabetic rat models using a high-fat and high-glucose diet, respectively combined with STZ in order to observe the expression of GRP78 protein, a molecular chaperone of ERS, in each group of cochleae, and investigated the molecular mechanism of hyperlipidemia and diabetes on inner ear damage. Here, HSPA5 is linked to obesity disorder.