ADGRA2 and breast cancer: In the multivariate Cox proportional hazards regression model, after adjusting for age at diagnosis, clinical characteristics, and treatment, a higher ADGRA2 expression in BC cells significantly increased the risk of BCSS (hazard ratio [HR]: 8.042, 95% confidence interval [CI]: 1.874–35.012, P = 0.005) and DFS (HR: 2.487, 95%CI: 1.193–5.183, P = 0.015) events in the NACBC validation set.