Interestingly, this observation demonstrates a correlation between the mechanism of hsa_circ_0050386 interaction with the RNA-binding protein, Serine and arginine-rich splicing factor 3 (SRSF3), resulting in the downregulation of Fibronectin 1 (FN1) during NSCLC progression. The gene discussed is FN1; the disease is non-small cell lung carcinoma.