To comprehensively understand the downstream target genes of RBM5 in AML, we performed genome-wide transcriptome analysis by RNA-seq in the leukemia cell line MOLM13 with both RBM5 knockout (RBM5 KO) and RBM5 overexpression (RBM5 OE) compared to wild-type controls. This evidence concerns the gene RBM5 and acute myeloid leukemia.