Based on the results of the clinical research and public database (TCGA), we have summarized 9 Cardio-miRNAs that are reported targeting at PTEN (Fig. 2A, Table 1), such as miR-19a (GC, HCC, RCC) [54–56], miR-21 (UC, HCC, NSCLC, CRC, GBM, ccRCC, RCC, PC) [57–62], miR-25 (BC, HCC) [63, 64], miR-92a/b (HCC, OC, GBM) [65–67], miR-106b (BC, CRC) [68, 69], miR-130b (BC, NSCLC, OS, RCC) [70–73], miR-146b (TC) [74], miR-210 (NSCLC) [75] (Fig. 3). Here, PTEN is linked to hepatocellular carcinoma.