Adding to the previously reported positive role of ODC1 inhibition, we conclude that long-term astrocytic inhibition of ODC1 in AD not only halts neurodegeneration by reducing the production of toxic by-products from the urea cycle [4] but also supports regeneration by reversing the metabolic state of astrocytes from a toxic reactive state to a beneficial, neuro-supportive state. Here, ODC1 is linked to Alzheimer disease.