ODC1 and Alzheimer disease: Taking our current data together with previous reports, we state that the long-term inhibition of ODC1 can have a significantly positive effect on AD pathology, not just by facilitating complete Aβ plaque clearance without GABA and H2O2 production, but also by initiating synapse supportive and anti-apoptotic processes within the astrocytes, thereby supporting neuroregeneration (Fig. 4).