NEFL and frontotemporal dementia: To this, we considered blood NfL measurements, already shown to be increased in both sporadic and genetic FTD, particularly during the conversion from the presymptomatic to symptomatic phase, even if not specific for the disease [7, 35, 36], and anterior cingulate cortex atrophy, which is scored easily by visual rating scales at single subject level and has been shown to be specific for FTD [25, 37, 38].