To do this, we applied the win ratio approach to data from a trial (COMET; NCT02782741) in late-onset Pompe disease (LOPD; ORPHA:420429), a rare, progressive autosomal recessive glycogen storage disorder caused by bi-allelic pathogenic variants in the GAA gene encoding the lysosomal alpha-glucosidase [9, 10]. This evidence concerns the gene GAA and disorder of glycogen metabolism.