AR and Familial prostate cancer: Another interesting evidence has been reported about the link of IDH mutation on codon 132 or of 2-HG high levels and the higher cell invasion capacity of prostate cancer cells negative for the androgen receptor (AR); indeed, the authors showed that when AR is expressed it reverses the pro-tumorigenic effect of 2-HG via transforming growth factor (TGF)β1 and circRNA-51217 [45].