Moreover, also the anti-oxidant enzyme superoxide dismutase 2 (SOD2) has been shown to be indirectly involved also in the sustainment of succinate accumulation through a decreased activity of SDH and, intriguingly, an enhanced expression of Glut1 and glucose uptake in prostate cancer models [47], however these evidence need further validations in other biological systems. The gene discussed is SOD2; the disease is prostate carcinoma.