In addition, in HPV-associated cervical cancer and high grade squamous intraepithelial lesion patients, NK cell-activating receptors like NKp30 and NKp46 is downregulated and this leads to reduced NK cell cytotoxic activity and as well, cervical cancer patients exhibited a downregulation of NKG2D as well [12]. This evidence concerns the gene KLRK1 and cervical cancer.