NCR1 and squamous cell intraepithelial neoplasia: In addition, in HPV-associated cervical cancer and high grade squamous intraepithelial lesion patients, NK cell-activating receptors like NKp30 and NKp46 is downregulated and this leads to reduced NK cell cytotoxic activity and as well, cervical cancer patients exhibited a downregulation of NKG2D as well [12].