it is found that patients diagnosed with HAM/TSP had notable decreases in the occurrence of CD56+CD3−, CD56+CD16+, CD56+, and CD56dim cells, except for CD56bright cells and CD56+CD3+ NKT cells, when compared to the frequencies observed in asymptomatic carriers (ACs) and seronegative individuals (SN). The gene discussed is NCAM1; the disease is tropical spastic paraparesis.