We found that there were significantly lower serum levels of osteocalcin in Hepc1-/- mice than those in WT mice, and the serum levels of CTX-1 were also notably higher, indicating that increased osteoclast activity caused by iron accumulation may also be involved in the development of osteoporosis, which is consist with previous observations in the iron accumulation model either by extraneous iron intervention [36] or by genetic engineering [37]. Here, BGLAP is linked to osteoporosis.